The study subjects were 157 AN-exposed male shift workers who had been exposed to AN for 17 years on the average and 537 control workers whose working conditions were similar to those of the AN-exposed workers. It is classified as a Class 2B carcinogen (possibly carcinogenic) by the International Agency for Research on Cancer (IARC), and workers exposed to high levels of airborne acrylonitrile are diagnosed more frequently with lung cancerthan the rest of the population. ... failed to detect any health effect attributable to AN. These clinics specialize in Direct contact of your skin with acrylonitrile will damage the skin so that it may blister and peel. Key words: Acrylonitrile, Carcinogenicity, Acute health effects, Chronic health effects, Occupational exposure limit Introduction Acrylonitrile (AN) is a colorless and volatile liquid with the boiling point of 77.3°C. This compound is a major chemical intermediate, employed in creating such products as pharmaceuticals, antioxidants, and dyes, as well as in organic synthesis. Registry (ATSDR). 1.5 What levels of exposure have resulted in harmful health effects? A) IARC Carcinogenicity Ratings for CAS107-13-1 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 1) The agent (mixture) is possibly carcinogenic to humans. A) DNA damage, unscheduled DNA synthesis, mutations, chromosome aberrations, sister chromatid exchanges, oncogenic transformation, and other genetic effects have been induced in a variety of short-term assay systems. B) TOXICOLOGY: Acrylonitrile can be toxic by the inhalation, ingestion, and dermal exposure routes. Much of the toxicity of acrylonitrile is thought to be due to metabolic generation of cyanide; symptoms are similar to those induced by cyanide, but with slower onset. Toxic effects are due primarily to the bioreactivity of acrylonitrile with cellular proteins and to its epoxide intermediate that is mutagenic and genotoxic. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. It also functions as a pesticide fumigant. Potential health effects following exposure to acrylonitrile 4. Dermal contact may result in erythema, dermatitis, a burning sensation, and blister formation. In Evaluation of Short-Term Acrylonitrile is toxic by all routes, is readily absorbed and causes systemic toxicity in addition to local toxicity [1]. Global Health Humans Maximum Allowable Concentration Mice Neoplasms / chemically induced* Neoplasms / epidemiology Neoplasms, Experimental / … The objective of this study was to reveal the health effects of acrylonitrile (AN) in seven Japanese acrylic fiber manufacturing factories. Acrylonitrile: health effects, incident management and toxicology Information on acrylonitrile (2-propenenitrile; cyanoethylene; vinyl cyanide) for … ATSDR can also tell you the location of occupational and environmental health clinics. 1) Tachycardia has been reported following acute exposures. AS/SAN and ABS are higher quality plastics with increased strength, rigidity, toughness and temperature and chemical resistance. The report summarizes and evaluates information relevant to a preliminary interim assessment of adverse health effects associated with specific chemicals or compounds. 1.6 Is there a medical test to determine whether I have been exposed to acrylonitrile? 2) SEVERE TOXICITY: Lactic acidosis, tachycardia, gastrointestinal hemorrhage, anemia, leukocytosis, renal dysfunction, hepatitis, rhabdomyolysis, seizures, coma, respiratory failure, and death have been reported with more severe exposures. A number of epidemiological studies of persons occupationally exposed to acrylonitrile have found excess cancers of the colon, prostate, and respiratory system, and … Email: Contact CDC-INFO. Acrylonitrile increases cancer in high dose tests in male and female rat… Acute (short-term) exposure of workers to acrylonitrile has been observed to cause mucous membrane irritation, headaches, dizziness, and nausea. Acrylonitrile can also be absorbed through the skin in quantities sufficient to cause adverse health effects. IRIS assessment development process. • N-2-cyanoethylvaline (CEV) in blood and cotinine in urine were also determined.In non-smokers, a dose-response relation was observed between CEV and short-term health effects. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Acrylonitrile is highly flammable and toxic at low doses. The burning material releases fumes of hydrogen cyanide and oxides of nitrogen. Note: Javascript is disabled or is not supported by your browser. Health effects of acrylonitrile in acrylic fibre factories. Acrylonitrile. A) Chronic exposures have been associated with liver damage. In some instances, an agent, mixture or exposure circumstance for which there is inadequate evidence of carcinogenicity in humans but limited evidence of carcinogenicity in experimental animals together with supporting evidence from other relevant data may be placed in this group. Acrylonitrile is a SUSPECTED HUMAN CARCINOGEN. It undergoes explosive polymerization. The six factories were classified into three groups on the basis of AN concentration at workplaces. ----- EPA Report No.560/7-81-007 July 1981 ENVIRONMENTAL AND HEALTH ASPECTS OF ACRYLONITRILE A Comprehensive Bibliography of Published Literature 1930 - 1981 by Management Support Division Information Support Services Branch Office of Toxic Substances Washington, D.C. 20460 68-06-5836 Project Officers Michael Weaver, Delores Evans Management Support Division … This category is used for agents, mixtures and exposure circumstances for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals. It is widely utilized in synthetics, surface coatings, plastics, and adhesives manufacturing, especially in the form of acrylic and modacrylic fibers. Route of occupational exposure The primary route of acrylonitrile exposure is via inhalation, with an average respiratory retention of 52 per cent. These symptoms disappear when the exposure is stopped. Acrylonitrile is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. 888-232-6348 (TTY) Health Effects of Acute / Single Exposure Human Data General toxicity Acrylonitrile is an irritant, causing severe irritation with any tissues which it may come into contact with. For this reason, some items on this page will be unavailable. C) EPIDEMIOLOGY: Exposures are uncommon, but deaths have been reported. Acrylonitrile; CASRN 107-13-1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . The substance may cause effects on the central nervous system. 1.4 How can acrylonitrile affect my health? Following a train accident with acrylonitrile, 191 evacuated residents filled in questionnaires. [failed verification] ABS is amorphous and therefore has no true melting point.ABS is a terpolymer made by polymerizing styrene and acrylonitrile in the presence of polybutadiene. Acrylonitrile forms adducts with biological macromolecules. Health effects. Effects also depend on the health of a person or the condition of the environment when exposure occurs. Acrylonitrile Fact Sheet. 1990. A number of epidemiological studies of persons occupationally exposed to acrylonitrile have found excess cancers of the colon, prostate, and respiratory system, and excess deaths from lymphatic, stomach, and lung cancer. EXPOSURE & HEALTH EFFECTS; Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. The relationship between the degree of exposure and biological effects of acrylonitrile (AN) was studied in 102 workers whose exposure period exceeded five years, and in 62 matched controls, all of whom had been randomly sampled from six acrylic fibre factories in Japan. It is a pungent smelling, colorless flammable liquid with the chemical formula CH 2 CHCN. Acrylonitrile (CAS 107-13-1) is a clear, colourless, highly flammable liquid with a mild, unpleasant odour. It undergoes explosive polymerization. The exposure circumstance entails exposures that are possibly carcinogenic to humans. Programme, the International Labour Organization, or the World Health Organization. Get the latest public health information from CDC: https://www.coronavirus.govGet the latest research information from NIH: https://www.nih.gov/coronavirus, PDF documents can be viewed with the free Adobe® Reader. Is a clear, colourless, highly flammable liquid with the chemical formula CH 2.! 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